Rigidity Detection in Parkinson's Disease

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Chris Kao Project Team: Kylen Bares Eddie Cao Dr. Changquing (Chris) Kao, M.D., Ph.D.

Research Associate Professor in Department of Neurosurgery at Vanderbilt University Clinical interest: Microelectrode brain mapping for target localization of deep brain stimulation treatment of movement disorders

Research focus: Electrophysiology in nerve stimulation, epilepsy, pain control and head injury What is Parkinsons Disease? Neurodegenerative disorder caused by damaged or dead dopamine-neurons in the substantia nigra

Dopamine: neurotransmitter that carries information from neuron to neuron and eventually out to the muscles Brain no longer able to direct or control muscle movement in a normal manner. Half a million people every year are affected by Parkinsons

Symptoms Tremor or trembling in hands, arms, legs, jaw, and face Rigidity or stiffness of the limbs and trunk Slowness of motor movements Postural instability or impaired balance and coordination Reduced blink rate of eyes

Treatment Drugs: Levodopa/ L-Dopa Drugs designed to mimic dopamine effects or counteract acetylcholine effects Pallidotomy: Section of globus pallidus removed Deep Brain Stimulation (DBS) : Implants

stimulators that block brain signals causing rigidity, tremors and other symptoms http://www.pdmdcenter.com/articles/HopkinsWeb/index.html http://www.pdmdcenter.com/articles/HopkinsWeb/index.html Problem Quantifiable measurement of the symptoms of Parkinsons disease is

needed to maximize therapy. Unfortunately, there currently does not exist a method known to be reliable. Our Proposed Device Diagnostic tool that uses pneumatic cylinders to cause movement of the arm before and during DBS surgery. Displays the pressure needed to move the arm. This pressure is multiplied by the cross-sectional

area of the cylindrical piston to calculate the force. Force needed to move the arm is directly proportional to the rigidity of the muscle. Our Device A pneumatic-actuated frame that fits around the right arm - uses air pressure for individual flexion of the fingers, hand, and forearm

- measures the pressure exerted on the actuator piston - this pressure corresponds to the force needed to move the arm and, therefore, the rigidity of the arm muscles Each patient will be their own control since we only need to measure effectiveness of treatment Our Device Composed of two main parts

Control Box Contains the pneumatic valves and pressure manifold Arm frame Encloses the arm and translates motion of pneumatic cylinder into motion of arm Current Status Acquired materials for control box and

pneumatic actuators for arm frame Control box is complete, pending a minor change in tube layout. Acquired access to a life-size dummy to design our frame around Ultimate Goals To create and test the viability of a fully controllable pneumatic device that forces movement in the arms of actual

Parkinsons patients and accurately displays the required pressure to induce movement. To enable the device to adjust in order to comfortably fit multiple patients.

Recently Viewed Presentations

  • Tropical Medicine : Dengue Fever

    Tropical Medicine : Dengue Fever

    Dengue Fever- Clinical Course. Markers for more serious disease include severe abdominal pain, persistent nausea, and vomiting, bleeding mucosa, difficulty breathing (pulmonary edema), hypovolemic shock, abrupt thrombocytopenia, and increased hematocrit due to hemo-concentration.
  • 7장 소프트웨어 공학과 IPT - Tistory

    7장 소프트웨어 공학과 IPT - Tistory

    7장 소프트웨어 공학과 IPT. ... 총괄 도표(Overview Diagram) : 시스템 또는 프로그램의 개괄적인 사항을 입력, 처리, 출력의 관계로 도형 목차에 나타난 전체적인 기능을 하나의 도표로 나타낸 것 ... 체제배경도(Context Diagram), 자료 ...
  • HP standard light template

    HP standard light template

    HP Tarihçesi HP ve Büyüme HP Soy Ağacı Zorlu Şartlarda Başlangıç Teknoloji tarihinin en büyük birleşmesi Piyasa kuşkuyla yaklaştı Vekalet savaşı kızıştı BT piyasası pek parlak değil Müthiş Özen Gerektiren Bir Süreç Birleşme - Öncesi Program Yönetimi Değer Yaratmaya Odaklı...
  • The Big Talker FM - UNCW Faculty and Staff Web Pages

    The Big Talker FM - UNCW Faculty and Staff Web Pages

    The Big Talker FM Talk 103.9 & 106.3 WLTT Bryce Clark Amy Graham Adam Wade Station Identification Affiliated with Fox News Owned by Sea-Comm Media, Inc. Sea-Comm Media owns and operates 93.7 / 103.7 The Bone 103.9 and 106.3 The...
  • Quadratic Functions - Thomasville High School

    Quadratic Functions - Thomasville High School

    Quadratic Function A function written in the form f(x) = ax2 + bx + c, where a 0. quadratic term linear term constant term Classifying Functions Determine whether each function is linear or quadratic.
  • EFSA Bee Guidance Document - circabc.europa.eu

    EFSA Bee Guidance Document - circabc.europa.eu

    EFSA Bee Guidance. EFSA published in 2013 the Guidance on the risk assessment of plant protection products on bees (Apismellifera, Bombus spp. and solitary bees).After more than 5 years of discussions, only few MS agreed to its full implementation, while...
  • China: Tang and Song Dynasties

    China: Tang and Song Dynasties

    Taoism (Daoism): Beliefs "tao" = the right way to live. Taoism emphasizes finding inner peace by living simply and in harmony with nature. Taoists also believe that government is unnatural and we are better off with as little government as...
  • The Crucible and mcCarthyism - Mrs. Mehrens' English Page

    The Crucible and mcCarthyism - Mrs. Mehrens' English Page

    The Crucible and mcCarthyism. Drama and Allegory. The Rise of Communism. First Red Scare - 1917-1920. Russian Revolution - 1919. People accused/jailed with little or no evidence . 1939 WWII - Russia, ally to USA. Alien Registration Act - 1940...