Development of the Heart 212 2004 Week 6

Development of the Heart 212 2004 Week 6 Avinash Bharadwaj Retrospect Trilaminar embryo Three germ layers Head and tail folds

Cardiovascular System The Heart Blood vessels Abnormal development Correlation Some Special Features Early development and function

Requirements of the foetus Non-functional lungs Placental circulation Planning for postnatal life Right-left passage essential during foetal life,

obliteration required immediately after birth. The phylogenetic sequence. Earliest Development Angiogenic cell clusters or Blood Islands

Blood cells and endothelium Cardiogenic Area Flat embryo Position of cardiogenic area

Head Fold Cardiac area Gut formation Pericardium and heart tube Later

The Heart Tube Venous and arterial ends Regions defined

Bulbus cordis Ventricle Atrium Sinus venosus Conus and Truncus? The Tube Bends

V B V D A SV The Chambers

A A A V BVL

Left Front The Interior A-Ar R and L atria Atrioventricular

canal : common Outflow Aortic arches LA RA AVC

Left Right Partitioning

Interatrial septum Interventricular septum Spiral (aortico-pulomonary septum Endocardial cushions (A-V cushions) Functional requirements There must always be a right to left passage! Interatrial septum

Partitioning Right to left passage Mechanism for closing the passage

A V Septum Primum AVC V This is a sagittal

section seen from the right. Foramen Primum Foramen primum : Between the septum and

the AV Cushions Passage is a Must! Foramen secundum Foramen primum

about to disappear Septum Secundum To the right of primum Foramen primum has

disappeared Foramen ovale F. Ovale In septum secundum

Further The Valve Two septa

Two foramina Sinus Venosus Originally a symmetrical structure Right and left horns Venous return more to the right Left horn becomes smaller Opening shifts to the right Later part of right atrium

Left Atrium Four pulmonary veins Common opening Absorption of veins into atrium Rough part - auricle The Ventricular Septum

Three Parts Interventricular septum AV Cushions Spiral Septum The Ventricular Septum R Membranous

Muscular Spiral (Aorticopulmonary) Foetal Circulation Very little pulmonary flow

Placental Circulation Right to Left Passages

IVC : Blood from placenta Ductus venosus F. ovale

Ductus arteriosus Changes At Birth Closure of interatrial septum

Closure of ductus arteriosus Closure of ductus venosus Congenital Heart Disease Septal Defects Atrial and Ventricular

Endocardial cushion defects Aorticopulmonary defects PDA Others

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