Development of the Heart 212 2004 Week 6 Avinash Bharadwaj Retrospect Trilaminar embryo Three germ layers Head and tail folds
Cardiovascular System The Heart Blood vessels Abnormal development Correlation Some Special Features Early development and function
Requirements of the foetus Non-functional lungs Placental circulation Planning for postnatal life Right-left passage essential during foetal life,
obliteration required immediately after birth. The phylogenetic sequence. Earliest Development Angiogenic cell clusters or Blood Islands
Blood cells and endothelium Cardiogenic Area Flat embryo Position of cardiogenic area
Head Fold Cardiac area Gut formation Pericardium and heart tube Later
The Heart Tube Venous and arterial ends Regions defined
Bulbus cordis Ventricle Atrium Sinus venosus Conus and Truncus? The Tube Bends
V B V D A SV The Chambers
A A A V BVL
Left Front The Interior A-Ar R and L atria Atrioventricular
canal : common Outflow Aortic arches LA RA AVC
Left Right Partitioning
Interatrial septum Interventricular septum Spiral (aortico-pulomonary septum Endocardial cushions (A-V cushions) Functional requirements There must always be a right to left passage! Interatrial septum
Partitioning Right to left passage Mechanism for closing the passage
A V Septum Primum AVC V This is a sagittal
section seen from the right. Foramen Primum Foramen primum : Between the septum and
the AV Cushions Passage is a Must! Foramen secundum Foramen primum
about to disappear Septum Secundum To the right of primum Foramen primum has
disappeared Foramen ovale F. Ovale In septum secundum
Further The Valve Two septa
Two foramina Sinus Venosus Originally a symmetrical structure Right and left horns Venous return more to the right Left horn becomes smaller Opening shifts to the right Later part of right atrium
Left Atrium Four pulmonary veins Common opening Absorption of veins into atrium Rough part - auricle The Ventricular Septum
Three Parts Interventricular septum AV Cushions Spiral Septum The Ventricular Septum R Membranous
Muscular Spiral (Aorticopulmonary) Foetal Circulation Very little pulmonary flow
Placental Circulation Right to Left Passages
IVC : Blood from placenta Ductus venosus F. ovale
Ductus arteriosus Changes At Birth Closure of interatrial septum
Closure of ductus arteriosus Closure of ductus venosus Congenital Heart Disease Septal Defects Atrial and Ventricular
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